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KMID : 0043320100330060807
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Archives of Pharmacal Research
2010 Volume.33 No. 6 p.807 ~ p.811
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Synthesis and In Vitro Cytotoxicity of Cis-[Pt(NH3)(NH2OH)Cl2]
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Liu Wei-Ping
Ye Qing-Song
Chen Xi-Zhu
Yu Yao
Chang Qiao-Wen
Hou Shu-Qian
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Abstract
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A novel mixed NH3/NH2OH platinum(II) complex cis-[Pt(NH3)(NH2OH)Cl2] was synthesized and characterized by elemental analysis, FAB-MS, FT-IR and 1H NMR spectroscopy. This complex was determined to have a good water-solubility and satisfactory stability. The pertinent complex was evaluated for its in vitro cytotoxicity against 3AO, HCT-116, LNcap, A549/ ATCC and SGC-7901 human carcinoma cell lines. It shows appreciable cytotoxic activity that is comparable with cisplatin and is much more active than carboplatin.
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KEYWORD
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Platinum, Hydroxylamine, Synthesis, Antitumor
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